Trends in
Biomaterials & Artificial Organs
An International Journal Published by the 
Society for Biomaterials and Artificial Organs India
ISSN 0971-1198
Volume 15 Number 1 July 2001

p 1-3 Full Text

IMPROVING BLOOD-COMPATIBILITY OF POLYMERIC SURFACES

Denis Labarre
Biomateriaux et Polymeres, UMR CNRS 8612,
Universite Paris-Sud, Chatenay-Malabry,
France

Biocompatibility has been defined by consensus, but not blood-compatibility. The interactions between blood and a surface depend on the blood composition, the blood flow and the surface of the material defined by its physicochemical features. Blood response is sensitive to surface features such as surface area, crystallinity, hydrophobicity/hydrophilicity, outermost structure and surface chemistry. Material surfaces are not blood-compatible, resulting in triggering of the non-specific self-protection mechanisms of blood. Improving blood-compatibility of polymeric surfaces requires that the surfaces are able to delay, or to control locally the biochemical events implied in these responses. Strategies such as the "repelling brush" or the heparinised and heparin-like surfaces are currently developed to improve blood-compatibility of polymeric surfaces.

p 4-6 Full Text

PREPARATION OF WOUND DRESSING USING HYDROGEL POLYURETHANE FOAM

Jae-Suk Lee, Young-Sun Cho, Jin-Woo Lee, Hyun-Jung Kim1, Do-Gi Pyun1, Myung-Hwan Park1, Taek Rim Yoon2, Ho-Jin Lee3 and Yoshimitsu Kuroyanagy4

Department of Materials Science and Engineering, Kwangju Institute of Science and Technology (K-JIST), 1 Oryong-dong, Puk-gu, Kwangju 500-712, Korea.
Research Institute of C.C. Technology, Rm 701, Kowoon Institute of Technology Innovation, The University of Suwon, PO Box 77, Suwon, Korea1
Department of Orthopedics, Chonnam University Hospital, Kwangju, Korea2
Department of Polymer Science and Technology Engineering, Hannam University, Taejon, Korea3
Department of Plastic and Reconstructive Surgery, School of Medicine, Kitasato University, Kitasato 1-15-1, Sagamihara, Kanagawa, 228-8555, Japan4

The hydrogel type polyurethane (PU) foams were prepared from diisocyanate and polyol with/without hydrophilic moiety for wound dressing to protect infection from outside and to heal skin wound. Biomaterials with hydrogel properties, such as alginate and hyaluronic acid, and antimicrobial agent (silver sulfadiazine, AgSD) were also incorporated in the polyurethane foam. The PU foams have good properties such as mechanical strength, swelling ratio, and cell adhesion for applying to wound dressing. Especially, the wound healing effect of PU foam incorporated hydrogel materials with AgSD was excellent compared to that of PU foam without hydrogel materials.

p 7-11 Full Text

EFFICACY OF CHROME PROCESSED AORTIC ALLOGRAFT FOR CERVICAL OESOPHAGOPLASTY IN DOGS

T.P. Balagopalan and K.N. Muraleedharan Nayar
Department of Surgery
College of Veterinary and Animal Sciences
Mannuthy 680 651

Experimental cervical oesophagoplasty with chrome processed aortic allograft was performed in 12 dogs under general anaesthesia using triflupromazine hydrochloride and thiopentone sodium combination. Hyper alimentation intravenously and through pharyngostomy tube was employed postoperatively in 6 animals each. Morphological, histological and biomechanical studies were performed to assess the healing process. Proliferative changes in the vicinity of the graft material and the perioesophageal tissue were minimum. The grafted site showed satisfactory breaking strength, extensibility, energy absorption and total dilatation capacity on 60th postoperative day. The healing at the site was first intention healing characterized by early infiltration of polymorphs and macrophages followed by vascularisation and fibroplasia. Epithelialization was almost complete by 30th day, but by 60th day, epithelial lining was slightly hyperplasic and lamina propria was devoid of oesophageal glands. Presence of pharyngostomy tube did not influence the healing process.

p 12-16 Full Text

ORAL DELIVERY OF INSULIN- MAKING NEEDLES NEEDLESS

R. Narayani 
 Biochemistry Department, SRM Dental College & Hospital,
Bharathi Salai, Ramapuram Chennai  600 089

Abstract not available

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