|
Trends
in
GUEST EDITOR - Dr. T.S. Sampath Kumar, Indian Institute of Technology, Madras EDITORIAL Full Text p 20-30 Full Text BIOCOMPATIBLE
BIOMATERIALS : CURRENT STATUS AND FUTURE
PERSPECTIVES Viktor I.
Sevastianov Abstract not available p 31-36 Full Text
MICROENCAPSULATION OF FITC - BSA INTO POLY (e-CAPROLACTONE) BY A WATER- IN -OIL -IN -OIL SOLVENT EVAPORATION TECHNIQUE D.
Vijaya Ramesh1,*, N.
Medlicott2, M. Razzak2
& I. G. Tucker2 The
water -in oil-in - oil method
described in
this paper involves the use of a combination of
mixed solvent system
for the polymer and oil as processing medium to enable high entrapment
efficiency at the optimum processing conditions of the preparation. The
protein was encapsulated into poly (e-caprolatone)
microspheres using FITC labelled BSA as drug model. The different
procedures of microspheres preparation were followed with an aim to get
different particle size by changing the preparative variables such as the
polymer concentration, volume of the internal aqueous phase,
homogenization speed and stirring speed of the solvent evaporation. The
morphological characteristics of the particles and release profiles of the
labelled protein were analysed. In optimum conditions spherical and smooth
PCL microspheres were obtained with high encapsulation efficiency. The
particle size reduced as the concentration of the polymer solution
reduced. The homogenization speed did not show any effect on the particle
size and entrapment characters. The release of FITC-BSA lasted longer as
the particles size increased. The small size particles released more than
95% of the protein with
in 2 days. p 37- 41 Full Text CELL
SURFACE INTERACTIONS IN THE STUDY OF BIOCOMPATIBILITY Kumari.T.V*, Usha Vasudev, Anil Kumar & Bindu Menon Implantation
of materials in the body can lead to to adverse local and systematic
reactions. knowledge of basic mechanisms of cell material interaction and
better understanding of the ongoing processes at the cellular and
intracellular level during interaction of anchorage dependent cells with biomaterials will help in the development of new
biocompatible materials. As fibroblasts are the predominant tissue cell
coming in contact with most of the material in the body, mamalian
fibroblast cells were used for the study. Cell attachment and adhesion
pattern of cells on different materials were studied using microscopic
techniques. Fluorscent labelling of actin and vinculin of osteoblast cells
demonstrated a typical
sequence of events of cells as rounded, attachment with attachment
structures, microfilaments etc. p
42-47
Full
Text Medical
imaging with laser radiation, especially for early detection of cancer is gaining importance as this is based on refractive index
variation which is quite sensitive parameter in contrast to parameters
used in other diagnostic techniques. Optical scattering of various sheep
organs were measured by laser reflectometer and their surface reflectance
profiles were determined. Tissue equivalent optical phantoms for these
tissues were prepared from paraffin wax by mixing a specific combination
of wax color materials till the best fit surface profile of the phantoms
with that of their corresponding tissues were achieved. The optical
parameters absorption coefficient (µa), reduced scattering
coefficient (µs′) and anisotropy factor (g)
of tissues and phantoms were determined by Monte Carlo simulation
technique. Based on this technology tissue equivalent optical phantoms for
optical imaging of healthy and diseased organs could be developed and
their optical parameters determined. p 48-53 Full Text BETACYCLODEXTRIN
COMPLEXED INSULIN LOADED
ALGINATE MICROSPHERES - ORAL DELIVERY SYSTEM 2Sree
Chitra Tirunal Institute of Medical Science and Technology, Cyclodextrin (CD) form inclusion complexes with many drug
molecules. The complexed drug
have increased bioabsorption in invivo system.
The objective was to optimise the complexation concentration of
beta Cyclodextrin (BCD) with Insulin and encapsulate in alginate
microspheres. Inclusion
complex of BCD and Insulin were studied by polyacrylamide gel
electrophoresis (PAGE). The different concentrations of BCD (20mg, 50mg, 100mg, 200mg
and 500mg) complexed with 200 IU Insulin and the results depicted a
parabolic curve of complexation. A
study release of Insulin obtained with Insulin complexed with 100mg BCD.
The complexation was confirmed by thin layer chromatographic studies. The system used for the TLC were 5:3 ratio of phosphate
buffer pH 2.4 and acetonitrile. Another
noticeable fact is the chanage in complexation, which is found to be
inversely related to the concentration of BCD when it is above the
stoichiometric equivalent of the drug.
The alginate microspheres prepared by a new emulsification method
in presence of sequestering agent, sodium polyphosphate.
The released pattern of Insulin from Insulin and Insulin - BCD
complex encapsulated alginate microspheres were compared and the latter
showed release of Insulin for
six hours. p 54-56 Full Text POLYMERIC ALGINATE
FILMS AND ALGINATE BEADS FOR THE CONTROLLED DELIVERY OF MACROMOLECULES R.S.
Hermes* and R. Narayani The advances in recombinant DNA technology have ensured the easy and abundant availability of several genetically engineered regulatory and therapeutic proteins such as hormones, growth factor. However, their unstable and acid labile nature, short biological half lives, low bioavailability via certain routes which calls for repeated injections, large molecular size etc., have limited there effective role. The need of the hour is to develop novel strategies for the selective and effective delivery of their proteinaceous agents. The above limitations could be overcome by the entrapment of these macromolecular proteins in suitable polymeric matrices that release them in a controlled manner for long period of time at the target site. p 57-60 Full Text TOOTH RESTORED WITH COMPOSITE RESINS A COMPARATIVE ANALYSIS T.P.
Narasimha Bharadwaj*, Priscilla Solomon and A. Parameswaran Dentistry is that branch of Medical science which encompasses both the diseases of the mouth & the restoration of lost tooth structure. Teeth are constantly subjected to various diseases like Dental Caries which ravages its structure, necessitating restoration. Restorative procedures involves the use of biocompatible materials on the tooth to replace the lost tooth structure. The advocation of Composite Resins have opened up new vistas in the arena of Restorative Dentistry. The Fracture Resistance of three forms of composite resins used are evaluated & discussed. |
