You require Acrobat Reader for viewing Full Text. Download it FREE from ADOBE.
Click
here..........Back to the Journal Home Page
Trends
in Full text can be accessed by clicking on the pdf link. p 1-7 FULL TEXT
Finite Element Modeling and Experimental Validation of
Computational Procedures for a Fracture Mechanics Based Bone Test Method Satya Prasad Paruchuru* and Anju Jain *Visiting Research Professor, Hard Tissue Biomechanics
Laboratory, Department of Mechanical Engineering & Biomechanics,
University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249
(USA) Bone has a highly hierarchical structure and the bone
quality may be affected by factors at different length scales. Compact
Sandwich (CS) specimen serves as a better choice for macro scale fracture
toughness testing of bone, in cases of limited bone stock. In addition,
the configuration of CS specimen imparts itself the ability to serve as an
intermediary between micro and macro scale test methods. However certain
standardization aspects of CS specimen remain unaddressed. A reliable and
valid finite element (FE) model of CS specimen and procedures for the
numerical computation of fracture toughness parameters are necessary to
address the standardization aspects. An FE model of CS specimen was developed. FE meshing
criteria with reference to least dimension, crack tip element size, number
of crack tip elements, radial meshing criteria etc. were presented.
Fracture toughness tests were carried out using CS and compact tension
(CT) specimens in order to validate the FE model with experimental data.
Stress intensity factor and energy release rate were determined by finite
element analysis (FEA) and were compared with the theoretical solution and
experimental data. The statistically valid and reliable FE model will be
used for further analysis leading to the standardization of CS specimen. p
8-13 FULL TEXT
Thermally Stimulated Current Analysis in Human Blood M. S. Gaur*1, R. K.Tiwari1, Prashant Shukla1, Pooja
Saxena1, Karuna Gaur2 and Udita Tiwari3 1. Department of Physics, Hindustan College of Science and
Technology, Farah, Mathura (U.P.) Thermally stimulated current (TSC) analysis is an
extensive tool to understand the charge storage, charge relaxation and
electrets behavior of organic dielectrics and biomaterials. The present
paper studies the TSC behavior of blood. The TSC is recorded for the blood
of different groups donated by healthy donator, are characterized by
positive and negative peaks at temperature ranging 46-600C and 90-1100C
respectively. However, the TSC of blood donated by diabetic patient is
showing interesting behavior and characterized by two peaks of positive
polarity. The positive current peak position is subjected to glucose
concentrations. We report the TSC behavior of normal blood, diabetic blood
and pure glucose. p 14-19 FULL TEXT Polymeric Delivery Systems in Biotechnology: A Mini Review R .Narayani* Biochemistry
Department Intelligent delivery devices are indispensable for the commercial realization of biotechnology based therapeutics of the post genomic era. Controlled delivery approach will enable these therapeutics to access intracellular targets without metabolic inactivation and if required achieve genomic integration, high transfection efficiency and prolonged gene expression. Implantables, micro and nanoparticulate systems in which the agent is encapsulated for nuclear delivery will have great implications in the success of recent treatment modalities like gene therapy, RNA interference and antisense oligonucleotide based gene silencing. This review compares delivery from viral vectors with non viral polymeric vectors and examines the features and suitability of various types of polymeric vectors for the delivery of therapeutic biomolecules. p 20-28 FULL TEXT Hybrid Blended Polymer of Bacterial Surface Protein (Fimbriae = pili = BNT (Bionanotube) as an Important Vaccinating and Drug Delivery Tool : A Biomedical Design Nitosh Kumar Brahma*
Department of Chemical Engineering, Based on some preliminary biophysical experiments and routine scanning electron microscopical (SEM) observation, bionanotube (BNT) = fimbriae =pili of Escherichia coli has been considered for drug delivery and for vaccination uses. The concept of antiadherent immune response in Balb/c mice generated the use of hybrid blended polymer matrix in a continuous drug delivery and vaccinating process. BNT (bionanotube) of hybrid 5405 genetically engineered (GE) Escherichia coli C600) K-12, Yale strain was mixed with araldite to generate 100-200 nm diameter pores on the surface of blended polymer and were observed uder 400X microscope, performed water flow in contrast to pure araldite film (membrane) at the thickness of 1-2 mm. Hybrid 5405, genetically engineered (GE) non-pathogenic, MRHU (+) 70 MD plasmid, E.coli K-12 was isolated by coconjugation (recombinantions) of donor 026: enteropathogenic MRHU (+), 65 MD plasmid, transferred into E.coli K-12 C600 Yale auxotrophic strain. Balb/c mice were killed by the donors, pathogenic E.coli at lowest dose of LD50, 2 x 104 cell/ 0.2ml, compared to 5405 E.coli K-12 hybrid, GE, nonpathogenic strain and developed thereby the concept for using hybrid BNT for drug and vaccinating delivery. MRHU was an indirect indication of bacterial adherence and were identified at various plasmid profiles. p 29-62 FULL TEXT Surface Passivation and Controlled Ligand Supplementation of Cellular Activation Processes - Strategies for Bottom up Synthesis of Bioactive Surfaces K. Kaladhar, C.P. Sharma* Biosurface Technology
Division, BMT Wing This review emphasize on the underlying principles governing blood and tissue compatibility of biomaterials and various surface modification techniques. This could also be explored for development of functionally active nanobiomaterials. Here the role of chemical and physical stimuli, when ligands are present in the soluble or bound form in activating the biological system is extensively reviewed. Apart from that the current advances in surface modification strategies by bottom up method, or post synthetic surface modification at submicron to nano levels is discussed. Such improved surface modification strategies may have applications in drug delivery and other biomedical systems. p 63-72 FULL TEXT Three-Dimensional Anatomic Finite Element Modelling of Hemi-Arthroplasty of Human Hip Joint Ahmet C. Cilingira*, Vahdet Ucara, Recep Kazana School of
Mechanical Engineering, Esentepe Campus, Sakarya University, 54187,
Sakarya, Turkey Linear elastic finite element (FE) study was performed to investigate the contact mechanics and stress distribution of hemi-arthroplasty hip resurfacing using a metallic component. Three dimensional anatomic, three and two dimensional axisymmetric FE models were analyzed and compared in this study. The contact mechanics results show a good agreement between three FE models with approximately 0.5% difference between three-dimensional, anatomic and axisymmetric models and approximately 7% difference between three-dimensional, anatomic and two-dimensional, axisymmetric models. Significant differences were found in the maximum predicted von Mises stresses between anatomic and axisymmetric, finite element models. Stress shielding in the bone tissue was found to occur with the hip hemi-resurfacing prosthesis considered in this study. However, the stress shielding was shown to be less than those reported in literature for the MOM hip resurfacings and conventional total hip replacements. |
Copyright ©
2007 Society for Biomaterials and Artificial Organs (India).
You require
Acrobat Reader for viewing Full Text. Download it FREE from ADOBE.
Click
here
..........Back
to the Journal Home Page